Important Updates

Nov 9, 2022 - EvusheldTM Monograph updated with new dosing recommendations

  • Initial EvusheldTM dose for pre-exposure prophylaxis has been increased from 300 mg to 600 mg and recommendations for repeat dosing updated. See Clinical Practice Guideline for details.
  • Astra Zeneca communicated dosing changes and a reminder about potential for resistance.

Oct 26th, 2022 - Health Canada update on the use of EvusheldTM and potential resistance

  • EvusheldTM may not be effective against certain SARS-CoV-2 Omicron subvariants.
  • The Product Monograph for EvusheldTM has been updated with new information about the risk of prophylaxis and treatment failure due to antiviral resistance, including neutralization data on SARS-CoV-2 Omicron subvariants (BA.2.12.1, BA.2.75, BA.3, BA.4, BA.4.6, and BA.5).
  • Healthcare providers are advised to:
    • consider local epidemiology and individual exposure to circulating SARS-CoV-2 viral variants when making decisions regarding the use of EvusheldTM.
    • inform patients who receive EvusheldTM about the potential for a lack of effectiveness against certain SARS-CoV-2 viral variants.
    • instruct patients who receive EvusheldTM to seek medical advice if signs or symptoms of COVID-19 occur, persist or worsen.

Oct 18th, 2022 - EvusheldTM approved by Health Canada for treatment of mild to moderate COVID-19

 EvusheldTM had previously only been approved for pre-exposure prophylaxis of COVID-19.

  • Although there is evidence for the use of EvusheldTM and other monoclonal products in the treatment of COVID-19, there are significant concerns with resistance of emerging variants to these agents.
  • An official recommendation on the use of EvusheldTM for the treatment of mild to moderate COVID-19 in Saskatchewan is in development. At this time in Saskatchewan, EvusheldTM is not recommended for use in the treatment of COVID-19.


Clinical Practice Guidelines

Pre-Exposure Prophylaxis


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29 Nov 2022

Considerations for HCPs Infographic


Considering Evusheld?
10 Jun 2022

Evusheld™ Expiry Date Extension


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10 Aug 2022